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Their long-term effects on health are not yet known

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(c) Comparison of renal functional decline in smoking and never-smoking diabetic patients suggested that smoking cessation lowered blood cadmium concentrations within 3 months and reduced the hazard for renal functional deterioration

Consequently, endothelial dysfunction induced by e-cigarettes seems to occur even in the absence of nicotine, as it could be induced by the toxic metals contained and by the reduction in antioxidants such as vitamin E, for example [41]