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Our study demonstrated that methylated UBE2m increases the neddylation level and protein stability of NEDD4

Immediate medical attention is necessary if overdose is suspected

It is also important to note the dual effects of statinswidely used lipid-lowering drugson mitochondrial pathways

ROS-Glo H2O2 assay Oxidative stress was evaluated using the ROS-Glo H2O2 Assay (Promega, Madison, WI, USA) according to the manufacturers instructions

Acknowledgments Thank you to Mackenzie Langan for her assistance with the creation of challenge materials for this study, and to Shalini Ramachandra for her assistance with variable creation