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Nicotine levels can be reduced in various ways, by blending of tobacco leaves or using different types of paper or filters, per the report

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Although smoking rates have fallen globally but still smoking is likely to remain a leading cause of preventable death throughout this century unless smoking cessation efforts can significantly and rapidly reduce the number of people who smoke, particularly in the developing countries [128]

Susceptibility among tobacco naive youth is estimated between 9 and 21% (2)