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CJC-1295 is a tetrasubstituted version of the peptide that is also modified by adding a drug affinity complex (DAC) component called N-epsilon-3-maleimidopropionamide, which appears to bind to plasma proteins and may improve CJC-1295 pharmacokinetics

A 2022 clinical study found that a 0.5% GHK-Cu serum increased hair count by 22% over 16 weeks

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At the Endocrine Societys 2025 meeting, researchers reported that in 110 men, a 10% weight loss raised the share with normal total and free testosterone from 53% to 77% over 18 months