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Honestly, the jury is still out, and robust human clinical trials are lacking

Before any work, study the relevant documentation

The dose simply not working An incorrect dose, or one that mostly landed in fat, may mean your symptoms do not improve as expected

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Drug-induced hypertension: The following drugs may induce hypertension: Steroids and estrogens (including oral contraceptives) Alcohol Cocaine Cyclosporine and tacrolimus Sympathomimetics Erythropoietin Licorice (in chewing tobacco) Monoamine oxidase (MAO) inhibitors Tricyclic antidepressants Nonsteroidal anti-inflammatory drugs (NSAIDs) Adapted from JNC-7 Express, National Heart, Lung, and Blood Institute