In many countries, it is the main risk factor for non-communicable diseases (Oyuela-Caycedo and Kawa, 2015), this plant, especially Nicotiana rustica L., is associated with a strikingly different usage and repute (Russell, 2019): Tobacco is described as the main curing tool of Amazonian healers (Russell and Rahman, 2015)
Journal of Substance Abuse Treatment
That means even if a product doesnt contain tobacco leaf or stem, it can still be classified as a tobacco product if the nicotine inside comes from the tobacco plant
On the contrary, in many developing countries we see an increment of more than the 3% per year
According to CDC, emphysema is seen in 15-20 percent of heavy smokers