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In our opinion, when considering a new compound for clinical testing, it is important to have in vivo and in vitro studies confirming positive effects suggested by gene profiling as well as safety

Disorders of transsulfuration

Melatonin synthesis: acetylserotonin O-methyltransferase (ASMT) is strongly expressed in a subpopulation of pinealocytes in the male rat pineal gland

Author contributions Both authors contributed to the manuscript conception and design, read and critically reviewed and revised the work, approved the final submitted manuscript, and agree to be accountable for the work

This is not a compression injury or a partial damage model