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Hexane-soluble tobacco smoke extract may induce matrix metalloproteinase-1 expression in human skin fibroblasts through the activation of the aryl hydrocarbon receptor pathway, which is pathogenetically involved in extrinsic skin aging

I dont think of it in terms of being a tool, I dont think

We have seen how the Articles of Confederation had a Preamble in which the purposes of the union were common defense, the securities of their liberties, and their mutual and general welfare. The Constitutional Convention followed this precedent

this evidence, along with the prior findings, was evaluated and classified as described in the 2004 report

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