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232 were excluded as they were reviews, 138 were cell or animal studies, 36 were not focused on PD, 19 did not study specific environmental exposures, 16 did not test any epigenetic markers, six were book chapters, six were conference reports of previously excluded papers and four were meta-analyses (Fig

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Tobacco companies are banned from advertising in certain locations to certain audiences, these direct bans include: national TV and radio, local magazines and newspapers, billboard and outdoor ads, and ads on the Internet