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These add substantial costs that research suppliers do not bear

All of the velocities are given by Michaelis-Menten kinetics, with the K m values taken from the literature, and where available, from human data

Torkki M, Majuri ML, Wolff H, et al

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For instance, cascade multienzyme nanoparticles (e.g., PtMnIr) can deplete GSH, continuously generate ROS, and release damage-associated molecular patterns (DAMPs) to promote dendritic cell maturation and cytotoxic T lymphocyte infiltration [161]