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My great uncle's autobiography (Self-Portrait, Gilbert Frankau, Hutchinson 1940) mentions that he was commissioned to write an advertising leaflet for Carreras in 1928

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3a, blood samples from smokers incubated without any exogenous stimulus secreted significantly ( p 35 display a reduction in CD8 + and an increase in CD4 + T cells such that their CD4/CD8 ratio is more than double that of controls 20