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The center represents the 5 end degradation site, and shows where there is low ribosomal occupancy, middle ribosomal occupancy and stalled ribosomes at the degradation site
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Key clinical features include: Progressive exertional dyspnea the cardinal symptom, initially on exertion and advancing to rest in severe disease Dry, nonproductive cough persistent and often refractory to standard antitussives Bibasilar inspiratory crackles (Velcro crackles) present in ~80% of IPF patients on auscultation Digital clubbing present in up to 50% of IPF cases
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