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Oral administration Oral delivery is the most convenient route but presents bioavailability challenges

In the peptide therapy context, AbbVie's Lupron (leuprolide) franchise treating prostate cancer, endometriosis, uterine fibroids, and precocious puberty via GnRH agonism remains a stable legacy contributor, while Botox Therapeutic ($748 million in Q1 2024 alone) constitutes a significant peptide-adjacent revenue stream

Two features of the preclinical dose-response data are particularly relevant for researchers designing studies

Bacteriostatic Water for Injection, USP is: chemically designated H2O and is a sterile, non-pyrogenic preparation of water containing 0.9% (9mg/mL) of benzyl alcohol added as a preservative and has a pH of 5.7 (4.5 - 7.0)

The gap between promising preclinical data and clinical application comes down to understanding exactly which pathways BPC-157 targets and why those pathways matter more than prokinetic drugs that only address downstream symptoms