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Pathogenic potential can be down-regulated in order to maintain commensalism or upregulated in order to harm tissues of the host and obviate or alter immune surveillance negatively 66

Funding Research reported in this publication was supported by P50CA180907-03S1, K01CA253234 (MJB), and R21CA234968 (MJB) from the National Cancer Institute and the FDA Center for Tobacco Products (CTP)

American Indians started using tobacco for medical practices, as it was believed it cures everything from relieving pain to dressing wounds

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