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In individuals with bipolar disorder, the prevalence of chronic liver disease was as high as 13.9%, which is 2.7 times higher than the general population

As non-genotoxic agents, peroxisome proliferators have demonstrated apparent thresholds for carcinogenesis under the experimental conditions studied (Bentley et al

Furthermore, mutant p53 has been shown to inhibit the activity of the antioxidant transcription factor Nrf2, which may lead to reduced expression of SLC7A11, a component of the x c cystine-glutamate antiporter, and thus decreased levels of GSH 39

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