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Moreover, the FDA has requested premarket tobacco product applications (PMTA) for e-cigarette products on the market after February 2007 and used flavors as a criterion to disapprove nearly 1 million e-cigarette flavored products [91]

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Moreover, several participants mentioned using smoking as a means to alleviate anger and escape from problems, expressing concerns that without smoking, their anger issues would intensify, and they would struggle to cope with mental distress