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Regarding the effect of nicotine protonation in the e-liquid, nicotine benzoate e-liquid yielded a significantly higher nicotine bioavailability than unprotonated nicotine e-liquid (Product E (ePen3.0MB18VP) versus Product D (ePen3.0BT18), respectively

It has been well-documented that mentholated cigarettes and other flavored tobacco products are responsible for the initiation of smoking among our youth, as well as the difficulty in successful quitting among established smokers