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Thirty-six were randomly assigned to different DPSC dose groups (ranging from 1 10 6 to 1 10 7 DPSCs per tooth, with nine injected with saline only), and 96 were randomly assigned to a single-injection group (1 10 7 /0.6 mL DPSCs), a double-injection group (1 10 7 /0.6 mL DPSCs 2), or a saline group, in a 1:1:1 ratio

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Consequently, the direction of LPA-LPAR signaling is primarily determined by the specific G protein subtypes coupled to the involved LPARs, which in turn drive downstream signaling cascades and ultimately regulate various cellular biological behaviors, including proliferation, survival, inflammatory responses, immune responses, migration, and differentiation