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Cancer Causes Control 13:8390 Zhang Q, Tang X, Zhang ZF, Velikina R, Shi S, Le AD (2007) Nicotine induces hypoxia-inducible factor-1alpha expression in human lung cancer cells via nicotinic acetylcholine receptor-mediated signaling pathways

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PNE was found to alter norepinephrine transporter (NET) binding expression in both sexes and Catechol-O-methyl transferase (COMT)-dependent dopamine turnover in males

Food and Drug Administration warns consumers that they have not been approved for that purpose