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These microbial changes correlated with oncogenesis-related gene functions, highlighting the role of the oral bacteriome in oral carcinogenesis among smokeless tobacco users [76]

Further research is required to accurately assess the risks associated with new tobacco products, including the effects of secondhand smoke exposure

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However, a decreasing tendency was observed in benign breast adenoma (female mice fed with tobacco), malignant skin basal cell carcinoma (female mice fed with water extract of tobacco blend), and benign thyroid follicular cell adenoma (male rats fed with water extract of tobacco blend)

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