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The current Directive entered into force on 19th May 2014 and became applicable in the EU Member States on 20th May 2016

For the images of cigarettes, offered by current and former e-cigarette users, synonyms were most frequently mentioned, followed by risky (Table 2)

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Thus, 16HBE cells stimulated with cigarette smoke extract (CSE) exhibited a concentration- and time-dependent increase in Lsm2 gene expression, with the highest elevation observed after 1.5% CSE stimulation for 72 h (Fig