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(S)-(-)-Cotinine activates nicotinic acetylcholine receptors ( nAChR ) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451)

According to Hukkanen, J., Jacob, P.s 2005 study, Metabolism and disposition kinetics of nicotine., the pharmacokinetic properties of nicotine, or the way it is processed by the body, contribute to its addictiveness