If the same vial were diluted with 4mL instead, the concentration would be halved to 5,000mcg/mL, and the same 4,000mcg dose would require 0.8mL, or 80 units
This implies sodium channel inhibition, a blockade of voltage-gated sodium channels (VGSCs) leading to a reversible block of action potential propagation [278], and reduced permeability of cell membranes, thereby blocking depolarization and preventing the conduction of the electrical impulse through which pain occurs [279]
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Johnson, S., & Imai, S