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Additionally, if gut permeability is indeed increased in ME/CFS patients, microbes and antigens may be able to cross the epithelial barrier into surrounding tissue and blood, potentially crossing the BBB and altering the HPA axis (443)

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It also contributes to blood pressure and autonomic cardiovascular regulation, enhancement of immune function, and reduction of inflammation in the gastrointestinal tract

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First, reduce exposure to environmental toxins, pollutants, and chemicals whenever possible