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The question is whether that systemic dose is sufficient to have a meaningful impact on a peripheral joint like the knee compared to a direct subcutaneous injection

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If the peptide is administered once in a way that creates a short signaling event, that protocol is functionally different from the same total amount divided across separate administrations

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The pharmacological properties of APAP are the focus of some activity, with the role of the metabolite N -arachidonoylaminophenol (AM404) still a topic of debate