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The controversy reflects the relative degree of emphasis given to the potential harm to adolescents and young adults from using e-cigarettes at one pole compared with the potential for reduced risk for established adult users of conventional cigarettes at the other (if they transition completely to e-cigarettes)

Beyond Pleasure: Aversion Pathways While the mesolimbic dopamine system mediates nicotines rewarding effects, nicotine also activates the medial habenulainterpeduncular nucleus (MHbIPN) circuit, which produces aversive sensations such as nausea at high doses

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High PG (e.g., 50/50, 60PG/40VG) & Nicotine Salts: Best for Mouth-to-Lung (MTL) devices, such as most pod systems and vape pens