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Similarly, aerosol inhalation can result in enhanced airway resistance [45] and increased sympathetic nervous system activity [46], factors contributing to elevated risk for the development of cardiopulmonary disorders [10, 47]

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But, given that pouches are placed in the mouth in a relatively dry location and left still for long periods of time, there is a body of non-conclusive data showing that this usage regimen may create oral problems, such as gum disease, irritation, sensitivity or discoloration

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