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If this Government is serious about halving the gap in healthy life expectancy, they must be bold on smoking, which is responsible for half of that difference

Other participants referred to family factors (n=10), contextual factors (n=4), and former smokers success stories (n=2) (Table 2)

For example, Carpenter states that a comprehensive risk profile [for smokeless tobacco] remains unclear, despite numerous epidemiologic studies documenting minimal risks

Dysfunction of the ETC increases electron leakage, resulting in excessive production of ROS, such as O 2 , which attack nuclear DNA and induce oncogenic mutations (e.g., TP53 and CTNNB1 mutations) 72

19 November 2021