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Another disappointing outcome arose from the Selenium and Vitamin E Cancer Prevention Trial, which demonstrated that Se (200 g/d from l-selenomethionine (SeMet)), vitamin E, or Se+vitamin E did not prevent prostate cancer in healthy population groups of men in the study and also had no effect on secondary endpoints, which included lung cancer and colorectal cancer ( Reference Lippman, Klein and Goodman 29 )

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