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Inhalation of nicotine leads first to an increase in vascular tone, and then to a state of chronic spasm, which impairs tissue nutrition and contributes to a more rapid progression of diabetic angiopathy, which in turn worsens blood flow in the lower extremities and may lead to the need for their amputation

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The combination of red light (640 nm) and near-IR (830 nm) at low doses has also shown a beneficial effect for collagen synthesis 42