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Our products are intended for use by adults of legal smoking and vaping age in their relevant jurisdiction (e.g., 18 or older in California), and not by children, women who are pregnant or breastfeeding, or persons with or at risk of heart disease, high blood pressure, diabetes or taking medicine for depression or asthma, or who otherwise may be sensitive to nicotine

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Since nicotine is reported to directly potentiate cancer cell EMT 59 , we also examined its direct effect on cancer cells

Those who have smoked heavily for years are more likely to have intense symptoms