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Technically, they dont expire in a hazardous way, where smoking an old cigarette would make you sick (although, lets be real, smoking itself isnt exactly doctor-recommended)

Antioxidant capacity and clearance of free radicals are often used as important indexes to evaluate the body against oxidative and inflammatory damage, and these testing indicators mainly include catalase (CAT), superoxide dismutase (SOD) and some inflammatory factors (NF-B and TNF-) [32, 33]