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The long-term and immediate effects of nicotine and benzo[a]pyrene exposure on female reproduction have been explored using human cell lines, different animal models including rodents and Rhesus monkeys, and in clinical studies

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Mike DeWine of Ohio and Ted Kennedy of Massachusetts to authorize the FDA to regulate tobacco products and buy out struggling tobacco growers, but the House again failed to allow a vote.[25] Finally, on June 22, 2009, Congress passed a landmark bill, the Family Smoking Prevention and Tobacco Control Act, which gave FDA clear authority to regulate the manufacturing, advertising, and sale of tobacco products