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Broadly speaking, inflammatory macrophages increase production of proinflammatory cytokines IL-6, TNF, IL-1, and type I interferons that create a harmful feedforward immune cell recruitment-activation cycle 2,74,104,105

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Another study found that 200 and 400 mg/kg doses of quercetin reduced joint swelling and signs of acute inflammation in rats with MSU crystal-induced arthritis [1]