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Recent research demonstrates that nicotine exerts much more anti- than pro-inflammatory effects [6] and a recent review of animal literature in HIV and smoking concluded that preclinical studies using nicotine show mild cognitive enhancement, neuroprotective, and possibly anti-inflammatory effects [26]

The statistical analysis for the cardiovascular parameters was carried out after verification of the normal distribution via the Kolmogorov-Smirnov test via two-sided, paired t-tests within the parameters against the baseline, via an ANOVA at the individual time points between the products

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