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Your brain now requires more nicotine to activate the expanded receptor population, accelerating tolerance buildup

Its actually the polycyclic aromatic hydrocarbons from smoking that induce the enzyme (CYP1A2), and we dont see that effect with nicotine itself, whether from e-cigs, patch, or gum

These results are summarized in Table S1 in the supplementary materials

Previous studies in other systems showed that a broader set of quantitative plant leaf traits could better predict species-abundance sensitivities to precipitation, although the analytical framework differed from ours 13