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In particular, it was found that ephrin-B2 is able to control VEGF signalling by inducing VEGFR2 and VEGFR3 internalization, thereby regulating angiogenesis and lymphangiogenesis in physiological conditions as well as during tumor progression [169, 170]

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PMID 18444899.

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Collectively, these findings indicate that enhanced glutamine metabolism and cell growth dysregulation are established in K-Ras-driven cancer cells to promote uncontrolled cell growth and to assist with glutamine acquisition and utilization for cell growth