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The proposed manufacturing facility is designed with an annual production capacity ranging between 10 - 20 billion sticks, enabling economies of scale while maintaining operational flexibility

If it gets worse, it can lead to a serious gum disease called periodontitis

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May 2014 Study finds e-cigarettes 60% more effective than gum or patches Study leader Professor Robert West, said: E-cigarettes could substantially improve public health because of their widespread appeal and the huge health gains associated with stopping smoking

You can read more about nicotine poisoning on WebMD and Wikipedia.