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Research has also explored its association with inflammatory modulation and recovery mechanisms following tissue stress or injury

Disordered microbial communities in the upper respiratory tract of cigarette smokers

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japonicum , termed Sj 16, has also been shown to possess immunomodulatory properties, including a reduction in macrophage maturation, while also modulating cytokine production in thioglycolate-induced peritoneal mouse cells by upregulating IL-10 and IL-1RA, while downregulating MIP-2, IL-1 and IL-12p35 ( Sj 16 is also capable of increasing the abundance of CD4 + CD25 + Foxp3 + regulatory T cells, thereby suggesting that it not only has the capacity to downregulate inflammatory responses, but may also contribute to the development of a regulatory response (102)

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