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[13] Slave labor on tobacco plantations [edit] Aftermath of Legalization of Chattel Bondage in 1660s [edit] Following the legalization of chattel slavery, slaves slowly and steadily replaced white indentured servants

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Due to the downregulation of colonic CD4 T cell nAChRs controlled by IL-12, nicotine aggravated colonic inflammation with the development of wide-ranging mucosal cell death in the proximal colon, exhaustive crypt injury, entire goblet cell exhaustion, lamina propria ruination, and huge lymphocytic infiltration [62]

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Zhu B, Macleod LC, Kitten T, Xu P