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Infection with AH1N1 influenza virus in male C57BL/6J mice previously exposed to sodium arsenite (100 ppb for five weeks) resulted in higher morbidity, higher levels of CD8 + in the bronchoalveolar lavage fluid, and decreased number of dendritic cells in the mediastinal lymph nodes (172)

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These results stand in contrast to a purely dopaminergic reward theory, leading to a better understanding of the neurobiology of nicotine motivation and possibly to improved therapeutic treatments for smoking cessation.

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