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77 Differential methylation patterns of cg05575921, the most frequently replicated probe, located in the intronic region of AHRR , have also been associated with multiple smoking traits: CPD, serum cotinine, cumulative amount smoked (pack-years), and time since quitting

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Denicotinised cigarettes Nicotine plasma levels are associated with cigarette smoking behaviour and nicotine is considered the main factor driving cigarette addiction