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33 METHODS Trials Overview and Participants Efficacy and safety data were pooled from the 2 phase III trials of cytisinicline 3 mg tid, the ORCA-2 and ORCA-3 studies, and the nonpsychiatric cohort from the most recent and largest phase IV trial of varenicline, the EAGLES study

A handful of studies suggest a possible role for CBD in addressing social anxiety, including one in which individuals treated 90 minutes before a public speaking exercise felt less stressed than placebo-receiving peers

81 Available evidence has established that smoking during pregnancy increases foetal testosterone levels 82 which have been associated with an increased risk for autism, 83 and antisocial disorder later in life

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