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Acknowledgements This work was supported by the Funds for Creative Research Groups (81421063) and the National Natural Science Foundation of China (81570399, 81270042, 30901208, and 81773735) and the Program for New Century Excellent Talents In Heilongjiang Provincial University (1254-NCET-012)

Hallucinogens generally have a low risk of physical addiction, but psychological dependence develops with repeated use, especially with substances like LSD and DMT

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The psychological dependence is also significant, as users often associate the drug with certain activities, environments, or coping mechanisms, further complicating the process of quitting