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Critical specs include material type (plastic, metal, wood), diameter tolerance (0.5mm), wall thickness (1.2mm), and heat resistance (minimum 80C)

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The advantages of Option 1 include bolstering the overall message of health warnings, reduce false belief about risks, promote cessation, reduce appeal and purchase intent as well as susceptibility to smoking

Brain imaging shows that regular smoking keeps nAChRs nearly fully saturated, supporting the theory of receptor desensitization [25]

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