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To these ends and others, the director adds the value of high-contrast black-and-white cinematography, by the likes of Frederick Elmes ("Blue Velvet"), Robby Mller ( Breaking the Waves ), Ellen Kuras ( Eternal Sunshine of the Spotless Mind and director Tom DiCillo ( Living in Oblivion )

finally, CS-induced increased mediators with vasoconstrictor, pro-inflammatory, and remodelling activities and increased endoplasmic reticular stress and the unfolded protein response in endothelial cells [115]