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Kulkarni, A., & Banait, S

This review synthesizes factors linking COPD to cognitive impairment, including systemic inflammation (via proinflammatory cytokines and blood-brain barrier disruption), hypoxemia/hypercapnia (inducing oxidative stress and neuronal damage), acute exacerbations (exacerbating inflammation and persisting deficits), and comorbidities like obstructive sleep apnoea (OSA), cerebral microbleeds, and depression