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3,4 Further cytokine production can occur as the LL37/DNA complex can act as an auto-antigen by fitting into the groove of human leukocyte antigen-Cw6 that is then presented to the T-lymphocyte

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Cryogenic electron microscopy (cryoEM) structural analyses revealed that E27 replaces endogenous CRL4 substrate receptors, resulting in proper positioning of STAT2 for polyubiquitylation and subsequent proteasomal destruction to inhibit host IFN signalling