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Studies suggest other theories for why immunotherapy doesnt work for some people, including age, hormones, diet, and intestinal flora. While aging typically comes with reduced immune function, some larger studies have shown there isnt much difference in response between older people and younger people receiving ICI immunotherapy. There seems to be a disparity between how males and females respond to immunotherapy, with the benefit being more pronounced in males

Despite these increases in coverage, by the end of 2021, less than half of the U.S

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