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Description

This mechanism may be attributed to the interference with copper ion transport leading to increased ROS levels, mitochondrial dysfunction and reduced ATP production, ultimately inhibiting Cu/Zn SOD1 activity (136)

To examine AP1 promoter activity following copper-induced upregulation of FOS , FOSB , JUN , and JUNB , a luciferase reporter assay was performed in HepG2 and HepG2 ATP7B-KO cells